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UniProtKB - A4GDF1 (A4GDF1_9POXV)

Entry version 29 (07 Apr 2021)
Sequence version 1 (10 May 2017)
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Protein

DNA-directed RNA polymerase subunit

Gene

J4R

Organism
Vaccinia virus
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates. Responsible for the transcription of early, intermediate and late genes.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationImportedARBA annotation, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:J4RImported
Synonyms:VACV_BRZ_SERRO2_094Imported
ORF Names:44.1rMVA_083Imported, 44/47.1_rMVA_089Imported, 47.1rMVA_088Imported, 51.2rMVA_094Imported, List092Imported, LIVPclone14_104Imported, m8114RImported, mO114RImported, synVACV_107Imported, VAC_DPP10_107Imported, VAC_DPP11_107Imported, VAC_DPP12_107Imported, VAC_DPP13_107Imported, VAC_DPP15_107Imported, VAC_DPP16_107Imported, VAC_DPP17_107Imported, VAC_DPP19_107Imported, VAC_DPP20_107Imported, VAC_DPP21_107Imported, VAC_DPP25_107Imported, VAC_DPP9_107Imported, VAC_IHDW1_098Imported, VAC_TKT3_086Imported, VAC_TKT4_086Imported, VAC_TP3_101Imported, VAC_TP5_101Imported, VACAC2_107Imported, VACCL3_107Imported, VACli_107Imported, VACV-DUKE-104Imported, VACV_092Imported, VACV_CTGV_CM01_096Imported, VACV_IOC_B141_122Imported, VACV_IOC_B388_122Imported, VACV_TT10_116Imported, VACV_TT11_116Imported, VACV_TT12_116Imported, VACV_TT8_116Imported, VACV_TT9_116Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVaccinia virusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10245 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Varidnaviria › Bamfordvirae › Nucleocytoviricota › Pokkesviricetes › Chitovirales › Poxviridae › Chordopoxvirinae › Orthopoxvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotationImportedARBA annotation, VirionUniRule annotationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A4GDF1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the poxviridae DNA-directed RNA polymerase 22 kDa subunit family.UniRule annotationARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007937, RNA_Pol_22kDa_poxvir

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05273, Pox_RNA_Pol_22, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000744, RPO22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4GDF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQYNVKYLA KILCLKTEIA RDPYAVINRN VLLRYTTDIE YNDLVTLITV 
        60         70         80         90        100
RHKIDSMKTV FQVFNESSIN YTPVDDDYGE PIIITSYLQK GHNKFPVNFL 
       110        120        130        140        150
YIDVVISDLF PSFVRLDTTE TNIVNSVLQT GDGKKTLRLP KMLETEIVVK 
       160        170        180 
ILYRPNIPLK IVRFFRNNMV TGVEIADRSV ISVAD
Length:185
Mass (Da):21,342
Last modified:May 10, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4A289D674B3B9E0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY313848 Genomic DNA Translation: AAQ93193.1
AY313847 Genomic DNA Translation: AAR17939.1
AY678275 Genomic DNA Translation: AAW23507.1
AY678277 Genomic DNA Translation: AAW23789.1
DQ121394 Genomic DNA Translation: ABD52562.1
DQ377945 Genomic DNA Translation: ABD57626.1
DQ439815 Genomic DNA Translation: ABD98566.1
JN654976 Genomic DNA Translation: AEY72669.1
JN654977 Genomic DNA Translation: AEY72907.1
JN654978 Genomic DNA Translation: AEY73142.1
JN654979 Genomic DNA Translation: AEY73384.1
JN654980 Genomic DNA Translation: AEY73624.1
JN654981 Genomic DNA Translation: AEY73854.1
JN654982 Genomic DNA Translation: AEY74094.1
JN654983 Genomic DNA Translation: AEY74335.1
JN654984 Genomic DNA Translation: AEY74563.1
JN654985 Genomic DNA Translation: AEY74803.1
JN654986 Genomic DNA Translation: AEY75043.1
KC201194 Genomic DNA Translation: AGB75817.1
JX489135 Genomic DNA Translation: AGJ91264.1
JX489136 Genomic DNA Translation: AGJ91537.1
JX489137 Genomic DNA Translation: AGJ91807.1
JX489138 Genomic DNA Translation: AGJ92079.1
JX489139 Genomic DNA Translation: AGJ92354.1
KC207810 Genomic DNA Translation: AGK06565.1
KC207811 Genomic DNA Translation: AGK06778.1
KF179385 Genomic DNA Translation: AHB35734.1
KJ125438 Genomic DNA Translation: AIX98791.1
KJ125439 Genomic DNA Translation: AIX99013.1
KM044309 Genomic DNA Translation: AIX99215.1
KM044310 Genomic DNA Translation: AIX99420.1
KP233807 Genomic DNA Translation: AIZ72845.1
KT184690 Genomic DNA Translation: ALF05092.1
KT184691 Genomic DNA Translation: ALF05343.1
KT013210 Genomic DNA Translation: ALF36253.1
KX061501 Genomic DNA Translation: AND73930.1
KX781953 Genomic DNA Translation: AQY54870.1
MH341445 Genomic DNA Translation: AXN56151.1
MH341446 Genomic DNA Translation: AXN56392.1
MH341447 Genomic DNA Translation: AXN56633.1
MK314710 Genomic DNA Translation: QCI57113.1
MK314711 Genomic DNA Translation: QCI57312.1
MK314712 Genomic DNA Translation: QCI57508.1
MK314713 Genomic DNA Translation: QCI57706.1
MK336431 Genomic DNA Translation: QEG58904.1
MN974380 Genomic DNA Translation: QIB98358.1
MN974381 Genomic DNA Translation: QIB98593.1
MT227314 Genomic DNA Translation: QKE59774.1

NCBI Reference Sequences

More...RefSeqi		YP_232978.1, NC_006998.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3707552

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:3707552

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313848 Genomic DNA Translation: AAQ93193.1
AY313847 Genomic DNA Translation: AAR17939.1
AY678275 Genomic DNA Translation: AAW23507.1
AY678277 Genomic DNA Translation: AAW23789.1
DQ121394 Genomic DNA Translation: ABD52562.1
DQ377945 Genomic DNA Translation: ABD57626.1
DQ439815 Genomic DNA Translation: ABD98566.1
JN654976 Genomic DNA Translation: AEY72669.1
JN654977 Genomic DNA Translation: AEY72907.1
JN654978 Genomic DNA Translation: AEY73142.1
JN654979 Genomic DNA Translation: AEY73384.1
JN654980 Genomic DNA Translation: AEY73624.1
JN654981 Genomic DNA Translation: AEY73854.1
JN654982 Genomic DNA Translation: AEY74094.1
JN654983 Genomic DNA Translation: AEY74335.1
JN654984 Genomic DNA Translation: AEY74563.1
JN654985 Genomic DNA Translation: AEY74803.1
JN654986 Genomic DNA Translation: AEY75043.1
KC201194 Genomic DNA Translation: AGB75817.1
JX489135 Genomic DNA Translation: AGJ91264.1
JX489136 Genomic DNA Translation: AGJ91537.1
JX489137 Genomic DNA Translation: AGJ91807.1
JX489138 Genomic DNA Translation: AGJ92079.1
JX489139 Genomic DNA Translation: AGJ92354.1
KC207810 Genomic DNA Translation: AGK06565.1
KC207811 Genomic DNA Translation: AGK06778.1
KF179385 Genomic DNA Translation: AHB35734.1
KJ125438 Genomic DNA Translation: AIX98791.1
KJ125439 Genomic DNA Translation: AIX99013.1
KM044309 Genomic DNA Translation: AIX99215.1
KM044310 Genomic DNA Translation: AIX99420.1
KP233807 Genomic DNA Translation: AIZ72845.1
KT184690 Genomic DNA Translation: ALF05092.1
KT184691 Genomic DNA Translation: ALF05343.1
KT013210 Genomic DNA Translation: ALF36253.1
KX061501 Genomic DNA Translation: AND73930.1
KX781953 Genomic DNA Translation: AQY54870.1
MH341445 Genomic DNA Translation: AXN56151.1
MH341446 Genomic DNA Translation: AXN56392.1
MH341447 Genomic DNA Translation: AXN56633.1
MK314710 Genomic DNA Translation: QCI57113.1
MK314711 Genomic DNA Translation: QCI57312.1
MK314712 Genomic DNA Translation: QCI57508.1
MK314713 Genomic DNA Translation: QCI57706.1
MK336431 Genomic DNA Translation: QEG58904.1
MN974380 Genomic DNA Translation: QIB98358.1
MN974381 Genomic DNA Translation: QIB98593.1
MT227314 Genomic DNA Translation: QKE59774.1
RefSeqiYP_232978.1, NC_006998.1

3D structure databases

SMRiA4GDF1
ModBaseiSearch...

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3707552

Genome annotation databases

GeneIDi3707552
KEGGivg:3707552

Family and domain databases

InterProiView protein in InterPro
IPR007937, RNA_Pol_22kDa_poxvir
PfamiView protein in Pfam
PF05273, Pox_RNA_Pol_22, 1 hit
PIRSFiPIRSF000744, RPO22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4GDF1_9POXV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4GDF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: April 7, 2021
This is version 29 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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