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Entry version 62 (07 Apr 2021)
Sequence version 1 (26 Nov 2014)
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Protein
Submitted name:

DNA-binding response regulator

Gene

cusR_1

Organism
Acinetobacter baumannii
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi125 – 223OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST99

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationImportedARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNA-binding response regulatorImported
Submitted name:
Heavy metal response regulator transcription factorImported
Submitted name:
Response regulatorImported
Submitted name:
Transcriptional activator protein CusRImported
Submitted name:
Transcriptional regulatory protein CusRImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cusR_1Imported
Synonyms:copRImported
ORF Names:A7M79_05075Imported, ABC003_01618Imported, ABUW_3323Imported, B4R90_15980Imported, CPI82_08035Imported, EA722_05425Imported, FD887_01395Imported, FDO31_09950Imported, FJU36_06060Imported, FJV14_15265Imported, FR761_04130Imported, GNY86_09830Imported, GOD87_02545Imported, GSE42_02935Imported, HYI42_06735Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcinetobacter baumanniiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri470 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000439424 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000179791 Componenti: Unassembled WGS sequence
  • UP000032746 Componenti: Chromosome
  • UP000195460 Componenti: Unassembled WGS sequence
  • UP000269597 Componenti: Unassembled WGS sequence
  • UP000327158 Componenti: Chromosome
  • UP000223291 Componenti: Unassembled WGS sequence
  • UP000306363 Componenti: Unassembled WGS sequence
  • UP000424492 Componenti: Chromosome
  • UP000320149 Componenti: Unassembled WGS sequence
  • UP000325747 Componenti: Unassembled WGS sequence
  • UP000480739 Componenti: Unassembled WGS sequence
  • UP000320596 Componenti: Unassembled WGS sequence
  • UP000509773 Componenti: Chromosome
  • UP000480763 Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei514-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

PhosphoproteinPROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 116Response regulatoryInterPro annotationAdd BLAST115
Domaini125 – 223OmpR/PhoB-typeInterPro annotationAdd BLAST99

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1020672at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00383, trans_reg_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011006, CheY-like_superfamily
IPR001867, OmpR/PhoB-type_DNA-bd
IPR006291, PcoR
IPR016032, Sig_transdc_resp-reg_C-effctor
IPR001789, Sig_transdc_resp-reg_receiver
IPR039420, WalR-like
IPR036388, WH-like_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR48111, PTHR48111, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00072, Response_reg, 1 hit
PF00486, Trans_reg_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00448, REC, 1 hit
SM00862, Trans_reg_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46894, SSF46894, 1 hit
SSF52172, SSF52172, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01387, cztR_silR_copR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51755, OMPR_PHOB, 1 hit
PS50110, RESPONSE_REGULATORY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A090B8T6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRILLVEDEQ KTGDYLKQGL SEAGYITDWV TDGLSGKHQA LSEEYDLIIL
60 70 80 90 100
DVMLPKLDGW NIINDIRKSG KTMPILFLSA RDQIEDRVKG LELGADDYLV
110 120 130 140 150
KPFAFAELLA RIKTLLRRGQ QKEDSNIITI ADLELDLRKR RVTRAGQRID
160 170 180 190 200
LTAKEFALME LFMRRRGEIL PRALIASQIW DMNFDSDTNV VEVAIKRLRN
210 220
KIDSNFSPKL IQNIRGMGYV LEVEDDS
Length:227
Mass (Da):26,041
Last modified:November 26, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F17007ABC59BAA3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP008706 Genomic DNA Translation: AKA33019.1
CACTJA010000112 Genomic DNA Translation: CAA3757600.1
VJZY01000014 Genomic DNA Translation: KAB8130288.1
WPIP01000059 Genomic DNA Translation: MVM91818.1
WWCH01000001 Genomic DNA Translation: MYM76891.1
LYKQ01000111 Genomic DNA Translation: OIG99148.1
NCYH01000032 Genomic DNA Translation: OVL07489.1
NXDV01000004 Genomic DNA Translation: PHQ03489.1
CP042556 Genomic DNA Translation: QFH44612.1
CP046536 Genomic DNA Translation: QGW09415.1
CP058625 Genomic DNA Translation: QLG80140.1
RFBY01000011 Genomic DNA Translation: RSP78693.1
VAGE01000001 Genomic DNA Translation: TLT66635.1
VHEA01000043 Genomic DNA Translation: TPS00974.1
VHGX01000018 Genomic DNA Translation: TPU80245.1

NCBI Reference Sequences

More...
RefSeqi
WP_001221580.1, NZ_WYAS01000013.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AKA33019; AKA33019; ABUW_3323
ASF76031; ASF76031; CBI29_00634
OIG99148; OIG99148; A7M79_05075
OVL07489; OVL07489; B4R90_15980
OWK64776; OWK64776; CBE85_20095
PHQ03489; PHQ03489; CPI82_08035
QBY89195; QBY89195; E5D09_06735
QCP29857; QCP29857; FDF20_01845
SSQ33500; SSQ33500; SAMEA104305229_02668
SSR40559; SSR40559; SAMEA104305246_00826

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56286696

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|470.1314.peg.2449

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP008706 Genomic DNA Translation: AKA33019.1
CACTJA010000112 Genomic DNA Translation: CAA3757600.1
VJZY01000014 Genomic DNA Translation: KAB8130288.1
WPIP01000059 Genomic DNA Translation: MVM91818.1
WWCH01000001 Genomic DNA Translation: MYM76891.1
LYKQ01000111 Genomic DNA Translation: OIG99148.1
NCYH01000032 Genomic DNA Translation: OVL07489.1
NXDV01000004 Genomic DNA Translation: PHQ03489.1
CP042556 Genomic DNA Translation: QFH44612.1
CP046536 Genomic DNA Translation: QGW09415.1
CP058625 Genomic DNA Translation: QLG80140.1
RFBY01000011 Genomic DNA Translation: RSP78693.1
VAGE01000001 Genomic DNA Translation: TLT66635.1
VHEA01000043 Genomic DNA Translation: TPS00974.1
VHGX01000018 Genomic DNA Translation: TPU80245.1
RefSeqiWP_001221580.1, NZ_WYAS01000013.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAKA33019; AKA33019; ABUW_3323
ASF76031; ASF76031; CBI29_00634
OIG99148; OIG99148; A7M79_05075
OVL07489; OVL07489; B4R90_15980
OWK64776; OWK64776; CBE85_20095
PHQ03489; PHQ03489; CPI82_08035
QBY89195; QBY89195; E5D09_06735
QCP29857; QCP29857; FDF20_01845
SSQ33500; SSQ33500; SAMEA104305229_02668
SSR40559; SSR40559; SAMEA104305246_00826
GeneIDi56286696
PATRICifig|470.1314.peg.2449

Phylogenomic databases

OrthoDBi1020672at2

Family and domain databases

CDDicd00383, trans_reg_C, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011006, CheY-like_superfamily
IPR001867, OmpR/PhoB-type_DNA-bd
IPR006291, PcoR
IPR016032, Sig_transdc_resp-reg_C-effctor
IPR001789, Sig_transdc_resp-reg_receiver
IPR039420, WalR-like
IPR036388, WH-like_DNA-bd_sf
PANTHERiPTHR48111, PTHR48111, 1 hit
PfamiView protein in Pfam
PF00072, Response_reg, 1 hit
PF00486, Trans_reg_C, 1 hit
SMARTiView protein in SMART
SM00448, REC, 1 hit
SM00862, Trans_reg_C, 1 hit
SUPFAMiSSF46894, SSF46894, 1 hit
SSF52172, SSF52172, 1 hit
TIGRFAMsiTIGR01387, cztR_silR_copR, 1 hit
PROSITEiView protein in PROSITE
PS51755, OMPR_PHOB, 1 hit
PS50110, RESPONSE_REGULATORY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A090B8T6_ACIBA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A090B8T6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 26, 2014
Last sequence update: November 26, 2014
Last modified: April 7, 2021
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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