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Keyword - Parkinson disease (KW-0907)


Protein which, if defective, causes classic Parkinson disease. Parkinson disease is a complex multifactorial neurodegenerative disorder, usually occurring in late life, although an early onset and a juvenile form are known. Typical features are masklike facies, tremor of resting muscles, a slowing of voluntary movements (bradykinesia), festinating gait and postural instability. The signs and symptoms of the disease are the consequence of a striatal deficiency of dopamine, resulting from neuronal death in the substantia nigra. Parkinson disease is characterized by the presence of Lewy bodies, intraneuronal inclusions found in many brain regions which are not entirely specific to, but are a highly sensitive marker for, Parkinson disease.


  • Paralysis agitans
  • Parkinson's disease
  • PD




Parkinson diseaseDisease
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