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Keyword - Methotrexate resistance (KW-0487)


Protein that confers the ability to withstand methotrexate, an inhibitor of dehydrofolate reductase (DHFR). Methotrexate resistance occurs usually as a result of mutation or amplification of the DHFR gene.


  • Resistance to methotrexate


Biological process

Gene Ontology


response to methotrexate [ GO:0031427 ]


Methotrexate resistanceBiological process
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