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Keyword - Membrane attack complex (KW-0473)

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Component of the membrane attack complex which groups the complement plasma glycoproteins C5b, C6, C7, C8 and polymeric C9 on biological membranes. The complex forms transmembrane channels which displace lipid molecules and other constituents, thus disrupting the phospholipid bilayer of target cells leading to cell lysis by osmotic leakage. The formation of the membrane attack complex is the terminal step in the complement cascade.


Cellular component

Gene Ontology


membrane attack complex [ GO:0005579 ]


Complement pathwayImmunityMembrane attack complexCytolysisCellular componentInnate immunityBiological process
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