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Keyword - Li-Fraumeni syndrome (KW-0435)


Protein which, if defective, causes Li-Fraumeni syndrome (LFS), an autosomal dominant familial cancer predisposition syndrome associated with soft-tissue sarcoma, breast cancer, leukemia, osteosarcoma, melanoma, and cancer of the colon, pancreas, adrenal cortex and brain. Individuals with LFS are at increased risk for developing multiple primary cancers.


  • LFS
  • Sarcoma family syndrome of Li and Fraumeni
  • SBLA syndrome




Li-Fraumeni syndromeDisease
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